Ginkgo Cloud Lab
FreeStreamline protein expression and purification workflows.
Free · Opens the source repo
What Ginkgo Cloud Lab does
Ginkgo Cloud Lab is a web-based platform that provides remote access to Ginkgo Bioworks' advanced laboratory infrastructure. This skill allows users to submit and manage protocols for various protein expression and purification tasks, including cell-free systems, E. coli, and Pichia pastoris. The platform is designed for researchers and developers needing efficient and automated solutions to complex biological workflows. With a catalog organized into categories such as Expression & Purification, Characterization & Assay, and Method Onboarding, users can select from a variety of certified protocols tailored to specific needs.
The Ginkgo Cloud Lab utilizes Reconfigurable Automation Carts (RACs) equipped with robotic arms and industrial-grade software to execute protocols across 70+ instruments. Users can easily navigate the platform to choose protocols, prepare inputs, and manage pricing and ordering workflows. Additionally, the integrated EstiMate AI agent provides feasibility assessments and pricing for custom workflows, allowing users to explore options beyond the predefined protocols. This feature is particularly beneficial for those with unique experimental designs or specific requirements.
Whether you are working on protein expression for therapeutic development, enzyme characterization, or novel assay methods, Ginkgo Cloud Lab offers a streamlined process to enhance productivity. The platform supports a variety of assays, including mRNA synthesis, thermal shift assays, and enzymatic detection, making it a versatile tool for biologists and biochemists alike. The user-friendly interface and comprehensive protocol documentation ensure that researchers can efficiently manage their experiments from start to finish.
When to use it
Use this skill when you need to automate and streamline protein expression and purification processes in a remote lab setting.
When not to use it
This skill may not be suitable for users looking for hands-on experimental methods or those requiring immediate physical access to laboratory equipment.
What you can build with it
Automating Protein Purification
Researchers can automate the purification of proteins using the cell-free or E. coli protocols, saving time and ensuring consistent results.
Custom Protocol Development
Utilize the EstiMate AI agent to explore custom workflows that are not listed in the standard catalog, allowing for tailored experimental designs.
Rapid mRNA Synthesis
Quickly synthesize mRNA or circRNA using the IVT protocol, which is essential for various downstream applications in molecular biology.
How to install Ginkgo Cloud Lab
View source1. Install with the skills CLI
npx skills add k-dense-ai/scientific-agent-skills/ginkgo-cloud-lab --agent claude-code2. Or install it manually
Download the skill folder and drop it into ~/.claude/skills/ for all projects, or .claude/skills/ to scope it to one repo. Restart Claude Code so it picks up the new skill.
Anthropic's agentic coding CLI, and the reference implementation of Agent Skills. Drop a skill folder into ~/.claude/skills and Claude Code loads it automatically whenever a task matches the skill's description. Claude Code docs
Inside SKILL.md
Written by k-dense-aiGinkgo Cloud Lab
Overview
Ginkgo Cloud Lab (https://cloud.ginkgo.bio) provides remote access to Ginkgo Bioworks' autonomous lab infrastructure. Protocols are executed on Reconfigurable Automation Carts (RACs) -- modular units with robotic arms, maglev sample transport, and industrial-grade software spanning 70+ instruments.
The platform also includes EstiMate, an AI agent that accepts human-language protocol descriptions and returns feasibility assessments and pricing for custom workflows beyond the listed protocols.
The catalog is organized into Expression & Purification (in vitro / cell-free / E. coli / Pichia), Characterization & Assay, Method & Target Onboarding, and Specialty. Pick a protocol below, then read its reference file for inputs, outputs, the automated workflow, and ordering details.
Available Protocols
Expression & Purification - In vitro
| Protocol | Readout | Price | Turnaround | Status |
|---|---|---|---|---|
| IVT mRNA/circRNA Synthesis | qPCR (mRNA or circRNA, 384-well) | $99/sample | up to 12 business days | Certified |
Expression & Purification - Cell-free (E. coli CFPS)
| Protocol | Readout | Price | Turnaround | Status |
|---|---|---|---|---|
| Validate sequence expression | Go/no-go titer + purity (up to 1800 bp) | $39/sample | up to 10 days | Certified |
| Optimize expression conditions | DoE across 24 conditions | $199/sample | up to 11 days | Certified |
| Express + quantify (HiBiT) | Luminescence, no purification | $39/sample | up to 11 days | Certified |
| Express + purify (A280) | Strep-tag, A280 yield | $149/sample | up to 11 days | Certified |
| Express + purify minibinder | Strep-tag, A280, LabChip | $149/sample | up to 11 days | Certified |
| Express + purify (A280 + LabChip) | Strep-tag, A280 + purity/size | $159/sample | up to 12 days | Certified |
Expression & Purification - E. coli
| Protocol | Readout | Price | Turnaround | Status |
|---|---|---|---|---|
| Express + quantify (HiBiT) | Luminescence (up to 384 constructs) | $79/sample | up to 3 weeks | Certified |
| Express + purify (A280) | His-tag, A280 yield | $199/sample | up to 3 weeks | Certified |
| Express + purify minibinder | His-tag, A280 yield | $199/sample | up to 3 weeks | Certified |
| Express + purify (A280 + LabChip) | His-tag, A280 + purity/size | $209/sample | up to 3 weeks | Certified |
Expression & Purification - Pichia
| Protocol | Readout | Price | Turnaround | Status |
|---|---|---|---|---|
| Express + quantify (LabChip) | Secreted protein, size/purity (up to 96) | $89/sample | up to 4 weeks | Certified (New) |
Characterization & Assay
| Protocol | Readout | Price | Turnaround | Status |
|---|---|---|---|---|
| Express + thermal shift | SYPRO Orange Tm (Tonset, TM1-3) | $159/sample | up to 12 days | Certified |
| Detect enzymatic products (Echo-MS) | Substrate/product by Echo-MS | $44/sample | up to 13 days | Beta |
Method & Target Onboarding
| Protocol | Readout | Price | Turnaround | Status |
|---|---|---|---|---|
| Onboard Echo-MS method | Calibration curve, LOD/LOQ | $799/molecule | up to 3 weeks | Certified |
| Onboard SPR target | Validated SPR capture method | $1,399/target | up to 4 weeks | Beta |
Specialty
| Protocol | Readout | Price | Turnaround | Status |
|---|---|---|---|---|
| Generate fluorescent pixel art | UV photo, 7-color E. coli palette | $25/plate | up to 7 days | Beta |
Coming soon: Protein Expression and Binding Affinity Characterization (express + purify, then screen binding affinity against a target).
Choosing a Protocol
- Quick expressibility screen? Cell-free HiBiT ($39) or Validate sequence expression ($39).
- Need purified protein + yield? A280 tiers (cell-free or E. coli); add LabChip for purity/size.
- Difficult / membrane / disulfide / cofactor targets? Cell-free Optimize (24-condition DoE).
- Secreted or eukaryotic targets? Pichia expression.
- Screening de novo binders/minibinders? Cell-free or E. coli minibinder tiers, then SPR onboarding for kinetics.
- Enzyme activity / biocatalysis? Echo-MS enzymatic detection (onboard the analyte method first).
- Stability / developability ranking? Thermal shift assay.
- RNA (mRNA/circRNA)? IVT synthesis + qPCR.
General Ordering Workflow
- Select a protocol at https://cloud.ginkgo.bio/protocols
- Configure parameters (number of proteins/samples/molecules/targets, replicates, plates)
- Download the protocol's input template and upload inputs (FASTA/CSV/XLSX for sequence protocols; Design Tool for pixel art; vendor catalog numbers for onboarding)
- Add any special requirements in the Additional Details field
- Provide an email, agree to the protocol terms, and add to cart / submit to receive a feasibility report and price quote
For protocols not listed above, use the EstiMate chat (https://cloud.ginkgo.bio/estimate) to describe a custom protocol in plain language and receive a compatibility assessment and pricing.
Authentication
Access Ginkgo Cloud Lab at https://cloud.ginkgo.bio. Account creation or institutional access may be required. Contact Ginkgo at cloud@ginkgo.bio for access questions.
Key Infrastructure
- RACs (Reconfigurable Automation Carts): Modular robotic units with high-precision arms and maglev transport
- Catalyst Software: Protocol orchestration, scheduling, parameterization, and real-time monitoring
- 70+ integrated instruments: Agilent Bravo liquid handlers, Beckman/Labcyte Echo acoustic dispensers, BMG PHERAstar / Tecan Spark readers, Revvity LabChip, Bio-Rad CFX Opus, Nicoya Alto SPR, SciEx Echo-MS, Inheco/Cytomat incubators, and more
- Nebula: Ginkgo's autonomous lab facility in Boston, MA
Frequently asked questions about Ginkgo Cloud Lab
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