Research Operations — Domain Orchestrator

The Research Operations surface is how the enterprise plans, funds, scopes, and synthesizes research across four workstreams: clinical R&D, R&D finance, market research, and product research. This orchestrator forks its context, routes your inquiry to one of four sub-skills, then returns a digest. Heavy intake (protocol drafts, program ledgers, survey exports, interview transcripts) stays in the forked context.

This is the enterprise counterpart to the academic research/ domain. If your question is about finding literature, grants, or patents, use research/. If it is about planning, funding, scoping, or synthesizing research as an operational discipline, you are in the right place.

When to invoke

Symptom	Sub-skill
"We're designing a Phase 2 trial — what's the endpoint and sample size?"	clinical-research
"What's our R&D program burn, and is this cost CapEx or OpEx?"	research-finance
"What's the TAM for this product, and how do we survey the segment?"	market-research
"How many users do we interview, and how do we synthesize the findings?"	product-research

Routing logic (deterministic)

Same two-signal threshold pattern as commercial-skills. Single-signal → clarifying question. Mixed signals → highest-confidence first, chain second in a follow-up turn. Never silently chain.

Signal table

Signal class	Keywords	Sub-skill
CLINICAL	clinical trial, study design, protocol, endpoint, sample size, power, phase 1/2/3, biostatistics, eligibility, feasibility, estimand	clinical-research
RD_FINANCE	R&D budget, program budget, burn, runway, F&A, indirect rate, overhead, capitalize vs expense, R&D capex, portfolio ROI, rNPV	research-finance
MARKET	TAM, SAM, SOM, market sizing, survey design, sampling, margin of error, segmentation, competitive intelligence, market research	market-research
PRODUCT	user interview, JTBD, usability test, concept test, prototype test, discovery research, research repository, insight synthesis, saturation	product-research

Workflow (Matt Pocock grill discipline)

Derived from Matt Pocock's grill-with-docs pattern: explore-then-ask, one question per turn with a recommended answer, walk the decision tree depth-first, track dependencies, anchor every challenge in the research canon (references/ of each sub-skill).

Step 1 — Explore before asking

Check the user's working directory first:

• Is there a protocol draft, program ledger, TAM model, or interview guide already in the workspace?
• Does the inquiry already disambiguate the lane (e.g., "what sample size for a two-arm trial" — that's clinical-research, no question needed)?
• Is there an artifact filename that resolves the lane (protocol.json → clinical; program-budget.json → finance; tam-model.json → market; interview-guide.md → product)?

If the workspace resolves the lane, route silently.

Step 2 — If still ambiguous, ONE forcing question with a recommended answer

Matt's rule: never bundle. Always recommend.

Pattern:

Q1/1: [precise question naming the two candidate lanes]
Recommended: [Lane X, because <signal-table rationale>]

(Confirm, or override?)

Step 3 — Decision-tree walk for multi-lane inquiries

If the inquiry legitimately crosses two lanes (e.g., "design this trial AND budget it" = CLINICAL + RD_FINANCE), walk depth-first:

1. Highest-confidence lane first → run sub-skill in forked context → digest
2. Ask: "Now run [second lane]? Recommended: yes, because [dependency]."
3. Confirm before chaining.

Never silently chain.

Step 4 — Invoke sub-skill in forked context

Forward original prompt + structured inputs (protocol JSON, program ledger CSV, market model, observation export).

Step 5 — Return digest with cited canon challenge

≤ 200 words: analyzed, top 3 findings (anchored to a canon citation), top 3 next actions (named human owner where applicable), artifact path, and one grill challenge for the user. Examples:

• "Your power calc assumes a 0.5 effect size with no published anchor. ICH E9 requires a justified, clinically meaningful difference. Where did 0.5 come from?"
• "Your TAM is a single top-down number (1% of a $40B market). Bessemer market-sizing discipline requires a bottoms-up cross-check. What's units × price × adoption?"

Forcing-question library (grill-with-docs pattern)

Grill the user on lane-defining decisions before invoking the sub-skill. One per turn, recommended answer, canon citation:

• CLINICAL lane: "Is your primary endpoint a clinical outcome or a surrogate — and if surrogate, is it validated for this indication? Recommended: clinical outcome unless the surrogate is on FDA's validated table. Canon: FDA Surrogate Endpoint Table; BEST glossary."
• RD_FINANCE lane: "Is this spend in the research phase or the development phase, and can you evidence technical feasibility? Recommended: research = expense; development = capitalize-candidate only with feasibility evidence, routed to a named finance owner. Canon: IAS 38; ASC 730."
• MARKET lane: "Is your TAM top-down or bottoms-up — and have you computed it both ways to triangulate? Recommended: both; reconcile the delta. Canon: Bessemer / a16z market-sizing; Fermi estimation."
• PRODUCT lane: "Is this study generative (discover problems) or evaluative (test a solution)? Recommended: name it first; the method follows. Canon: Rohrer's landscape of UX research methods (NN/g)."

Never run a sub-skill until the lane-defining decision is locked.

Onboarding-first (per sub-skill)

Before invoking a sub-skill for the first time in a workspace, point the user at that skill's onboarding questionnaire so the tools run pre-configured to their context:

python3 skills/<sub-skill>/scripts/onboard.py          # interactive Q&A
python3 skills/<sub-skill>/scripts/onboard.py --show    # questions + current config

Each sub-skill has its own question set (clinical: area/alpha/power/dropout/owners · finance: area/F&A/runway/standard/owner · market: profile/confidence/MoE/method · product: profile/insight-threshold/method/stakes). Answers persist to ~/.config/research-ops/<sub-skill>.json (or ./.research-ops/<sub-skill>.json with --scope project) and are consumed automatically by every tool in that skill. Customization is mandatory discipline here, not decoration — surface the onboarding step when a user starts a fresh research workstream.

Autoresearch handoff (isolated, opt-in)

Each sub-skill ships its own skills/<sub-skill>/scripts/ar_evaluator.py — an isolated bridge to engineering/autoresearch-agent. Invoke autoresearch only when the user explicitly asks to "optimize", "improve", or "run a loop". The handoff is per-skill (no shared coupling): the loop edits the skill's input file and the evaluator scores it (clinical → feasibility_composite higher; finance → runway_months higher; market → tam_divergence lower; product → validated_insights higher). Never auto-start a loop; never let the loop edit the evaluator.

Assumptions

1. User has research authority OR is preparing analysis for someone who does.
2. User wants deterministic decision support, not the final answer — a clinician approves the protocol, a controller books the entry, the human picks the market number.
3. Inputs may be partial — every sub-skill ships a templated sample so the user can see the shape before filling in their own.

Non-goals

• Not an EDC, clinical-trial-management system, accounting system, survey platform, or research repository.
• Does not give clinical, accounting, or legal advice as fact. Every output is a recommendation + named human owner.
• Does not store research history across sessions.

Distinct from

• research/ (academic) — that domain finds literature, grants, and patents. This domain plans, funds, scopes, and synthesizes research.
• ra-qm-team — that's regulatory/QM submission (ISO 13485/14971, MDR, FDA 510(k)/PMA/QSR). clinical-research designs the study; it routes submission out to ra-qm-team.
• finance/financial-analysis — that's corporate close + valuation. research-finance manages R&D program/portfolio spend.
• research/grants — that's funding discovery. research-finance manages money already won.
• product-team — that's persona/journey artifacts, discovery sprints, and live A/B experiments. product-research is the method + repository discipline.
• marketing-skill — that's campaign analytics and demand-gen. market-research is upstream methodology.

Output artifacts

Sub-skill	Artifact
clinical-research	protocol_synopsis.md + sample_size.json
research-finance	rd_program_budget.md + capex_opex_routing.json
market-research	market_sizing.md + sample_plan.json
product-research	research_plan.md + insight_synthesis.json

Anti-patterns (do not)

• ❌ Present a clinical power/endpoint output as fact — it is an estimate with a named clinical owner
• ❌ Auto-decide capitalize-vs-expense — route to a named finance owner
• ❌ Report a market size as a single unsourced number — show method + both-ways triangulation + assumptions
• ❌ Assert a product insight from a single participant — flag it as an anecdote
• ❌ Run all 4 sub-skills "to be thorough" — pick one, digest, chain if needed

References

• Clinical canon: ICH E8(R1)/E9/E9(R1), CONSORT, SPIRIT, FDA Multiple Endpoints
• R&D finance canon: IAS 38, ASC 730, 2 CFR 200, Cooper stage-gate
• Market canon: Cochran, Dillman, Kotler, Bessemer market-sizing
• Product canon: Nielsen, Guest et al., Christensen JTBD, ResearchOps/Polaris
• Path-B build pattern: documentation/implementation/research-ops-expansion-plan.md